ChloroquineV1, France, Analysis, bibRecord, 000284

Cogniauxia podolaena: bioassay-guided fractionation of defoliated stems, isolation of active compounds, antiplasmodial activity and cytotoxicity.

Identifieur interne : 000284 ( France/Analysis ); précédent : 000283; suivant : 000285

Cogniauxia podolaena: bioassay-guided fractionation of defoliated stems, isolation of active compounds, antiplasmodial activity and cytotoxicity.

Auteurs : Jean Théophile Banzouzi [France] ; Patrice Njomnang Soh ; Bernard Mbatchi ; Adrien Cavé ; Suzanne Ramos [France] ; Pascal Retailleau [France] ; Olga Rakotonandrasana [France] ; Antoine Berry ; Françoise Benoit-Vical

Source :

Planta Medica [ 0032-0943 ] ; 2008-10.

RBID : Hal:hal-00345168

Abstract

COGNIAUXIA PODOLAENA Baill. (Cucurbitaceae) is traditionally used in Congo Brazzaville for the treatment of malaria. We assessed the antiplasmodial activity of the plant and isolated some of the compounds responsible for this activity. It was the first time that a chemical study of this plant has been undertaken. Three triterpenes were isolated: cucurbitacin B ( 1), cucurbitacin D ( 2) and 20-epibryonolic acid ( 3) and their structures were assigned from spectroscopic evidence and comparison with published data. The crystallographic structure of 3 was determined. All fractions and compounds obtained in this study were assayed for antiplasmodial activity (on FcM29, a chloroquine-resistant strain of P. FALCIPARUM) and cytotoxicity (on KB and Vero cell lines). The IC50 values of 1, 2 and 3 are 1.6, 4 and 2 microg/mL on FcM29. Both 1 and 2 have a high cytotoxicity whereas 3 shows a better selectivity index.

Url:

https://hal.archives-ouvertes.fr/hal-00345168

DOI: 10.1055/s-2008-1081341

Affiliations:

France

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000053
to stream Hal, to step Curation: 000053
to stream Hal, to step Checkpoint: 000205
to stream Main, to step Merge: 001923
to stream Main, to step Curation: 001917
to stream Main, to step Exploration: 001917
to stream France, to step Extraction: 000284

Links to Exploration step

Hal:hal-00345168

Le document en format XML

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<front><div type="abstract" xml:lang="en">              <p>COGNIAUXIA PODOLAENA Baill. (Cucurbitaceae) is traditionally used in Congo Brazzaville for the treatment of malaria. We assessed the antiplasmodial activity of the plant and isolated some of the compounds responsible for this activity. It was the first time that a chemical study of this plant has been undertaken. Three triterpenes were isolated: cucurbitacin B ( 1), cucurbitacin D ( 2) and 20-epibryonolic acid ( 3) and their structures were assigned from spectroscopic evidence and comparison with published data. The crystallographic structure of 3 was determined. All fractions and compounds obtained in this study were assayed for antiplasmodial activity (on FcM29, a chloroquine-resistant strain of P. FALCIPARUM) and cytotoxicity (on KB and Vero cell lines). The IC50 values of 1, 2 and 3 are 1.6, 4 and 2 microg/mL on FcM29. Both 1 and 2 have a high cytotoxicity whereas 3 shows a better selectivity index.</p>
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{{Explor lien
   |wiki=    Sante
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   |texte=   Cogniauxia podolaena: bioassay-guided fractionation of defoliated stems, isolation of active compounds, antiplasmodial activity and cytotoxicity.
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Cogniauxia podolaena: bioassay-guided fractionation of defoliated stems, isolation of active compounds, antiplasmodial activity and cytotoxicity.

Cogniauxia podolaena: bioassay-guided fractionation of defoliated stems, isolation of active compounds, antiplasmodial activity and cytotoxicity.

Source :

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri